The Second COVID-19 Shot Is a Rude Reawakening for Immune Cells

Mark Slifka, an expert in vaccines and immunologist at Oregon Health and Science University told me that it was the body’s reaction to infection. Let’s use antiviral cytokines to spray the area, which are also inflammatory.
Because of its unusual appearance, the mRNA might trigger an immune reaction. Donna Farber, an immunologist from Columbia University, says that suddenly, the cell produces a lot more RNA than it used to. She received her second dose of Moderna’s vaccine last month with few side effects.

Moderna’s shot, three times more genetic material than Pfizer’s, might be due to the provocative nature mRNA. This could explain why there were more side effects during clinical trials.

The innate immune system is quick to react. However, its actions don’t last very long and are not very discerning. These cells just clobber any object that is a little odd. They start to lose steam within a few days of the injection. Side effects begin to fade as cytokine production slows down. At this point, adaptive immunity cells and innate immune cells pass the baton to another division, called adaptive immune. This includes sniperlike molecules, cells and cells like antibodies and T cells that can launch an attack against specific pathogens if they attempt to infect the body.

The cells that make antibodies, T cells and B cells, take several days to learn the spike’s characteristics before they can react. However, adaptive cells can react much faster than the first injection and are ready to go by the time that the second injection arrives. Some cells were even lingering at injection sites, in the hope that their target would return. These sentinel cells can be stimulated again to produce cytokines and add an additional layer of inflammation. These complex reactions can lead to fevers, aches and long-term exhaustion in some people like my husband, the neurologist.

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