The Second COVID-19 Shot Is a Rude Reawakening for Immune Cells

Side effects that my husband experienced after the first dose included fatigue, headaches, dizziness, and fatigue. All of these side effects can be attributed to his innate immune system. After the second injection, those same innate reactions return for another round. However, the commotion after the second shot might have a double effect: The expected innate cell activity might be increased and amplified by an even slower surge of adaptive cells located near the site where the needle is inserted.

Marion Pepper, an immunologist from the University of Washington, said to me that everything responded with the second dose.

Pepper described her first dose of Pfizer’s vaccine “a piece cake.” However, the second shot left her with more severe flu-like symptoms. Side effects are a sign that both the immune system and the brain are working as they should. They cement the memory of coronavirus’s spike proteins in the most powerful cells of the body.

Slifka stated that vaccine boosters are crucial because of this. The first shot stimulates adaptive and innate immunity. However, the second injection reminds the B and T cells that there is a threat from the coronavirus and that they must be prepared for it.

“They are asking why this is happening 21 or 28 days after it happened?” Slifka stated, “I thought we took care this four weeks ago.”

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